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The Mexican economy is characterized by an extensive business fabric and entrepreneurial culture, which contributes to economic development, the social economy, and the proliferation of entrepreneurship. The effects are reflected in the quality of life, in the growth of employment, in the knowledge spillovers, and in the socioeconomic factors. This chapter offers a contextual review of enterprise creation in Mexico and its relationship on development and entrepreneurship. Following the Economic Censuses and National Survey on Productivity and Competitiveness of Micro, Small and Medium Enterprises (ENAPROCE in Spanish), the profile of entrepreneurs in the period 2009–2014 is analyzed. A conceptual contribution is made from the antecedents of the entrepreneurship to evaluate the success factors and determinants that influence the entrepreneurship in the context of Mexico. Within the findings, regions with entrepreneurial culture are precursors of a competitive process and impulse in employment; at the same time, regions with a low level of GDP per capita and low level of development register high rates of new enterprises, most classified as subsistence enterprises.