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The aim of the study is to understand the transformative impact of ChatGPT on artificial intelligence (AI) research, its applications, implications, challenges and potential to shape future AI trends. The study also seeks to assess the relevance and quality of research output through citation and bibliographic coupling analysis.

This study employed a comprehensive bibliometric analysis using Biblioshiny and VOSviewer to investigate the research trends, influential entities and leading contributors in the domain of AI, focusing on the ChatGPT model.

The analysis revealed a high prevalence of AI-related terms, indicating a significant interest in and engagement with ChatGPT in AI studies and applications. “Nature” and “Thorp H.H.” emerged as the most cited source and author, respectively, while the USA surfaced as the leading contributor in the field.

While the findings provide a comprehensive overview of the ChatGPT research landscape, it is important to note that the conclusions drawn are only as current as the data used.

The study highlights potential collaboration opportunities and signals areas of research that might benefit from increased focus or diversification. It serves as a valuable resource for researchers, practitioners and policymakers for strategic planning and decision-making in AI research, specifically in relation to ChatGPT.

This study is one of the first to provide a comprehensive bibliometric analysis of the ChatGPT research domain, its multidimensional impact and potential. It offers valuable insights for a range of stakeholders in understanding the current landscape and future directions of ChatGPT in AI.

Renal failure is an end-stage consequence after persistent hyperglycemia during diabetic nephropathy (DN), and the etiology of DN has been linked to oxidative stress. The purpose of this research was to determine the beneficial synergistic effects of S-Allyl Cysteine (SAC) and Taurine (TAU) on oxidative damage in the kidneys of type 2 diabetic rats induced by hyperglycemia.

Experimental diabetes was developed by administering intraperitoneal single dose of streptozotocin (STZ; 65 mg/kg) with nicotinamide (NA; 230 mg/kg) in adult rats. Diabetic and control rats were treated with SAC (150 mg/kg), TAU (200 mg/kg) or SAC and TAU combination (75 + 100 mg/kg) for four weeks. The estimation of body weight, fasting blood glucose (FBG), oral glucose tolerance test (OGTT), oxidative stress markers along with kidney histopathology was done to investigate the antidiabetic potential of SAC/TAU in the NA/STZ diabetic group.

The following results were obtained for the therapeutic efficacy of SAC/TAU: decrease in blood glucose level, decreased level of thiobarbituric acid reactive substances (TBARS) and increased levels of GSH, glutathione-s-transferase (GST) and catalase (CAT). SAC/TAU significantly modulated diabetes-induced histological changes in the kidney of rats.

SAC/TAU combination therapy modulated the oxidative stress markers in the kidney in diabetic rat model and also prevented oxidative damage as observed through histopathological findings.