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Burnout syndrome is characterized by exhaustion, cynicism, and inefficacy. Considered a work–stress-related condition, burnout first described professional activities that provide a direct service to people, such as the health and teaching professions. Recent scholarship, however, points to the existence of burnout in any kind of work and at any level of the organization. Some have noted a high prevalence of burnout in the general population, and especially increased prevalence among healthcare professionals. This chapter thus aims to analyze burnout syndrome, including its detection and prevention in organizations. It will proceed by reviewing classic and recent scientific literature on burnout, and its impact on the individual and the organization. It also evaluates organizational interventions meant to prevent burnout and help employees, as well as assess some coping strategies employees can take up to develop a healthier relationship with their jobs.