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A plethora of research has been carried out both in terms of addressing different conceptualizations of destructive leadership and its relationship with various outcomes. In this vein, this chapter focuses on the relationship between destructive leadership and followers' well-being. In particular, it addresses the current state of inquiry about the plausible effects of destructive leadership on the followers' mental and physical health, including experiences of stress, emotional exhaustion, and negative affectivity. Furthermore, it presents empirical research exploring the underlying mechanisms of this relationship. Finally, it proposes the implementation of occupational interventions to prevent and/or reduce destructive leadership behaviors and later provides recommendations for prospective research. Thus, the current chapter contributes to the extant literature by providing a comprehensive view regarding the detrimental effects of destructive leadership on the followers' well-being as well as offering insight into how to deal with its negative effects.