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The new standard ISO 45001 is expected to give a significant boost to the growth of the number of companies that have adopted and certified an occupational health and safety (OHS) management system. The structure of the new standard reflects the Annex SL, thus facilitating the organizations in aligning and integrating their management systems. The requirements of the standard lead companies, across the Deming Cycle, to the continual improvement of OHS performance starting from the essential process of leadership and commitment, through the implementation of the key processes of planning (context analysis, risk assessment, operational planning, and control), of the support processes (communication and participation, competence and awareness of resources, and documentation management) and, finally, the processes of performance evaluation (monitoring, auditing, and management review). The advantages are a full control of compliance obligations, a significant reduction in the injury indexes, a reduction in the associated costs, and an improvement in corporate image.