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Despite the existing gaps in the use of technology in East Africa, the region is among the fastest-growing mobile data users on the continent. This progress is partially attributed to local initiatives to develop and adapt homegrown technologies to local contexts to increase their accessibility and use even in the remotest areas. In this chapter we identify a few of these innovations in Kenya, Rwanda and Uganda and examine how they have been indigenised to fit local contexts as well as the processes of their diffusion, adoption, affordability and accessibility among users and their everyday gratifications from the innovations. The socio-technological assemblage theory, which illuminates the influences of, and the connections between various types of actors and their roles, visions, ideas, concepts and the technological products, informs our inquiry. Other related concepts including ‘innovation’, ‘indigenisation’ and ‘diffusion’ are discussed to understand the homegrown technology innovations and their adaptability. Discussions with both innovators and users/beneficiaries reveal rigorous proactiveness and responsiveness of innovation creators and users in the three countries – reflected in numerous attestations of life transformation. Nevertheless, there is a paradigm shift in the diffusion of innovations amongst users – contrary to the discourse around its early precepts.