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With the increasing urbanization rates in emerging countries such as the ones in Latin America and the Caribbean, urban logistics solutions and initiatives are widely needed. Urban planners often consider only passenger transportation and leave freight transportation unattended, thus increasing externalities and degrading the transportation of goods. This chapter presents three urban logistics solutions, which intend to tackle problems related to urbanization and last mile delivery operations challenges by evaluating location models for loading and unloading bays, urban transfer centers location models, and freight trip generation models. The presented solutions were proposed by several researchers of the Institute of Innovation in Productivity and Logistics CATENA-USFQ over the last four years and remain theoretical at the moment. However, we present estimated results of potential implementations in three districts of Quito: Historic Center, Entertainment District, and Corporate District. This chapter not only presents the mentioned urban logistics solutions in Quito but also gives an overview of the followed methodology, which can be replicated in countries and cities of similar characteristics of the region.